Blondel, DelphineLutolf, Matthias P.2019-04-022019-04-022019-04-022019-02-0110.2533/chimia.2019.81https://infoscience.epfl.ch/handle/20.500.14299/155873WOS:000461834200019Organoids have stepped into the limelight as unique in vitro systems for modeling organ development, function and disease. This review provides a perspective on how chemically defined, bio-inspired hydrogels could be used for replacing ill-defined matrices derived from the native extracellular matrix (ECM) that are used for generating organoids in 3D stem cell culture. In particular, we propose the use of self-healing and light-responsive matrices that should afford control over the inherently stochastic self-organization process that currently underlies organoid morphogenesis. Such designer ECMs could accelerate the translation of organoid technology from the laboratory into various real-life applications.Chemistry, MultidisciplinaryChemistryecmhydrogelmatrigel (tm)organoidphoto-patterningsynthetic gelself-healingintestinal stem-cellmorphogenesismatrixtext::journal::journal article::research article