GAMBY, J.ABID, J.-P.TRIBOLLET, B.GIRAULT, H. H.2008-05-212008-05-212008-05-21200810.1002/smll.200700778https://infoscience.epfl.ch/handle/20.500.14299/25858WOS:000257549100019A nanomosaic network of metallic nanoparticles for the detection of ultralow concentrations of proteins is reported, which uses two planar microelectrodes embedded in a microchip that permit generation of capacitive coupling to the nanomosaic system without the need for direct electrical contact with the channel. By tailoring the microchannel surface using a sandwich configuration of polyethylene terephthalate/gold nanoparticles/poly(L-lysine), the surface charge can be modified following biomolecular interactions and monitored using a noncontact admittance technique. This nanodevice system behaves like a tunable capacitor and can be employed for the detection of any kind of molecule. The femtomolar detection of an anionic protein, such as b- lactoglobulin in phosphatebuffered saline medium, is taken as an example.admittancecapacitorsnanoparticlespolymersproteinstext::journal::journal article::research article