Wagnieres, G.Depeursinge, C.Monnier, P.Savary, M.Cornaz, P.Chatelain, A.Van den Bergh, H.2011-02-012011-02-012011-02-01199010.1117/12.17649https://infoscience.epfl.ch/handle/20.500.14299/63680An apparatus is designed and realized to detect "early" cancer at the surface of the hollow organs in the human body by endoscopic means. The tumor is localized by the laser induced fluorescence of a dye (HPD) which concentrates selectively in the neoplastic tissue after intravenous injection. Fluorescence contrast between the tumor and its normal surroundings is enhanced by subtracting the background autofluorescence which occurs in both types of tissue. This is done by means of 2-color digital images manipulation in real-time. Preliminary clinical tests of the apparatus demonstrated the detection of carcinoma in situ in the esophagus.68335-15-9 (HPD) Role: BIOL (Biological study) (in tumor detection by laser-induced fluorescenceapp. for)tumor detection HPD laser fluorescencetext::conference output::conference proceedings::conference paper