Vogel, P.2005-11-092005-11-092005-11-09200110.2533/chimia.2001.359https://infoscience.epfl.ch/handle/20.500.14299/219790Intercellular communication is governed by interactions between surface oligosaccharides and glycoproteins. The biosynthesis of these molecules involves glycosidations catalyzed by glycosyltransferases and hydrolysis of O-glycosyl linkages catalyzed by glycosidases. Monosaccharide and disaccharide mimics such as carbasugars, iminosugars and C-linked disaccharides can be glycosidase or glycosyltransferase inhibitors. They are leads as new drugs to treat infective diseases and cancer. The preparation of a conduramine, a pentahydroxyindolizidine, and two C-linked disaccharides are outlined.anticancer vaccinecarbasugarconduramineC-disaccharideglycosidase inhibitorglycosyltransferase inhibitoriminosugarisolevoglucosenone'naked sugar'pentahydroxyindolizidineActive specific immunotherapyalphabeta-unsaturated carbonylcompound1-acylethenyl anion equivalentinfluenza-virusneuraminidasefucosyl-transferase genesderivatives naked sugarssialic-acid7-oxabicyclo<2.2.1>hept-2-ene derivativeshumanalpha-13-fucosyl-transferase-vc(1->3)-linked disaccharidestext::journal::journal article::research article