Uher, TomasAdzima, AdrianSrpova, BarboraNoskova, LibuseMarechal, BenedicteMaceski, Aleksandra MaleskaKrasensky, JanStastna, DominikaAndelova, MichaelaNovotna, KlaraVodehnalova, KarolinaMotyl, JiriFriedova, LucieLindner, JiriRavano, VeronicaBurgetova, AndreaDusek, PetrFialova, LenkaHavrdova, Eva KubalaHorakova, DanaKober, TobiasKuhle, JensVaneckova, Manuela2024-02-162024-02-162024-02-162023-10-1610.1177/13524585231197076https://infoscience.epfl.ch/handle/20.500.14299/203894WOS:001086455700001Background: Early diagnosis and treatment of patients with multiple sclerosis (MS) are associated with better outcomes; however, diagnostic delays remain a major problem.Objective: Describe the prevalence, determinants and consequences of delayed diagnoses.Methods: This single-centre ambispective study analysed 146 adult relapsing-remitting MS patients (2016-2021) for frequency and determinants of diagnostic delays and their associations with clinical, cognitive, imaging and biochemical measures.Results: Diagnostic delays were identified in 77 patients (52.7%), including 42 (28.7%) physician-dependent cases and 35 (24.0%) patient-dependent cases. Diagnosis was delayed in 22 (15.1%) patients because of misdiagnosis by a neurologist. A longer diagnostic delay was associated with trends towards greater Expanded Disability Status Scale (EDSS) scores (B = 0.03; p = 0.034) and greater z-score of the blood neurofilament light chain (B = 0.35; p = 0.031) at the time of diagnosis. Compared with patients diagnosed at their first clinical relapse, patients with a history of >1 relapse at diagnosis (n = 63; 43.2%) had a trend towards greater EDSS scores (B = 0.06; p = 0.006) and number of total (B = 0.13; p = 0.040) and periventricular (B = 0.06; p = 0.039) brain lesions.Conclusion: Diagnostic delays in MS are common, often determined by early misdiagnosis and associated with greater disease burden.Life Sciences & BiomedicineDelayed DiagnosisMisdiagnosisBrain LesionMagnetic Resonance ImagingNeurofilamentCerebrospinal FluidDisabilityMultiple Sclerosistext::journal::journal article::research article