Schlosser, ManfredGeneste, Herve2006-03-032006-03-032006-03-03199810.1002/(SICI)1521-3765(19981002)4:10%3C1969::AID-CHEM1969%3E3.0.CO;2-Ohttps://infoscience.epfl.ch/handle/20.500.14299/226951A superior route to the analgesic flurbiprofen has been devised. Key steps are the selective deprotonation of 3-fluorotoluene with tert-butyllithium in the presence of potassium tert-butoxide (LIT-KOR) at the 4-position and the selective deprotonation of the 4-methyl-2-fluorobiphenyl with lithium diisopropylamide in the presence of potassium tert-butoxide (LIDA-KOR) at the benzylic position. Depending on the reagent and the substituent pattern, the 3- and 5-positions of 2-fluorobiphenyls can also be specifically attacked. [on SciFinder (R)]Metalation (regioselective; super base approach to flurbiprofen via regioselective metalation); Regiochemistry (super base approach to flurbiprofen via regioselective metalation)flurbiprofen prepn regioselective metalation super basetext::journal::journal article::research article