Carboni, CaterinaBisoni, LorenzoCarta, NicolaPuddu, RobertoRaspopovic, StanisaNavarro, XavierRaffo, LuigiBarbaro, Massimo2016-07-192016-07-192016-07-19201610.1007/s10544-016-0043-5https://infoscience.epfl.ch/handle/20.500.14299/127287WOS:000376579800013The prototype of an electronic bi-directional interface between the Peripheral Nervous System (PNS) and a neuro-controlled hand prosthesis is presented. The system is composed of 2 integrated circuits: a standard CMOS device for neural recording and a HVCMOS device for neural stimulation. The integrated circuits have been realized in 2 different 0.35 mu m CMOS processes available from ams. The complete system incorporates 8 channels each including the analog front-end, the A/D conversion, based on a sigma delta architecture and a programmable stimulation module implemented as a 5-bit current DAC; two voltage boosters supply the output stimulation stage with a programmable voltage scalable up to 17V. Successful in-vivo experiments with rats having a TIME electrode implanted in the sciatic nerve were carried out, showing the capability of recording neural signals in the tens of microvolts, with a global noise of 7 mu V-rms, and to selectively elicit the tibial and plantar muscles using different active sites of the electrode.Multi-channel neural recordingNeural stimulationBioelectronic devicestext::journal::journal article::research article