Pseudoproline libraries for tuning inhibitors of SH3 domain mediated protein-protein interactions

Fernandez-Carneado, JimenaDurieux, PatriciaPatiny, LucTatsu, YoshiroGrell, DanielKardinal, ChristianFeller, StephanTuchscherer, Gabriele2006-02-092006-02-092006-02-092001https://infoscience.epfl.ch/handle/20.500.14299/222279A symposium report. Pseudoprolines such as Ser, Thr, Cys derived proline-ring structures with enhanced inherent properties of L-Pro were used to evaluate ligand receptor interaction of Pro-rich peptides. The generation of pseudoproline-libraries exhibiting enhanced proline properties allows for rapid screening of a large no. of proline-rich peptides in the search of potent inhibitors of Src homol. (SH3)-mediated interactions. [on SciFinder (R)]Pseudoproline libraries for tuning inhibitors of SH3 domain mediated protein-protein interactionstext::conference output::conference proceedings::conference paper