Cobas, M.Wilson, A.Ernst, B.Mancini, S. J.MacDonald, H. R.Kemler, R.Radtke, F.2006-12-052006-12-052006-12-05200410.1084/jem.20031615https://infoscience.epfl.ch/handle/20.500.14299/23731614718516Beta-catenin-mediated Wnt signaling has been suggested to be critically involved in hematopoietic stem cell maintenance and development of T and B cells in the immune system. Unexpectedly, here we report that inducible Cre-loxP-mediated inactivation of the beta-catenin gene in bone marrow progenitors does not impair their ability to self-renew and reconstitute all hematopoietic lineages (myeloid, erythroid, and lymphoid), even in competitive mixed chimeras. In addition, both thymocyte survival and antigen-induced proliferation of peripheral T cells is beta-catenin independent. In contrast to earlier reports, these data exclude an essential role for beta-catenin during hematopoiesis and lymphopoiesis.AnimalsB-Lymphocytes/cytology/immunologyCell DifferentiationCell DivisionChimeraCytoskeletal Proteins/deficiency/genetics/*physiologyFemaleHematopoiesis/genetics/*physiologyIntegrases/geneticsLymphopoiesis/genetics/*physiologyMiceMiceInbred C57BLMiceKnockoutPhenotypeProto-Oncogene Proteins/genetics/physiologyResearch SupportNon-U.S. Gov'tSignal TransductionT-Lymphocytes/cytology/immunologyTrans-Activators/deficiency/genetics/*physiologyWnt Proteinsbeta Catenintext::journal::journal article::research article