Synthesis of alpha -keto amides by a molecular-sieves-promoted formal oxidative coupling of aliphatic aldehydes with isocyanides

Grassot, Jean-MarieMasson, GeraldineZhu, Jieping2010-11-252010-11-252010-11-25200810.1002/anie.200704840https://infoscience.epfl.ch/handle/20.500.14299/58417The reaction of an aldehyde, an isocyanide, N-methylhydroxylamine, and acetic acid in the presence of 4-.ANG. mol. sieves afforded alpha -keto amides in moderate to good yields. In contrast, 3-.ANG. mol. sieves did not promote the desired multicomponent reaction. [on SciFinder (R)]Amides Role: SPN (Synthetic preparation)PREP (Preparation) (oxo; synthesis of alpha -keto amides by a mol.-sieves-promoted formal oxidative coupling of aliph. aldehydes with isocyanides); Coupling reaction; Molecular sieves (synthesis of alpha -keto amides by a mol.-sieves-promoted formal oxidative coupling of aliph. aldehydes with isocyanides); Aldehydes; Isocyanides Role: RCT (Reactant)RACT (Reactant or reagent) (synthesis of alpha -keto amides by a mol.-sieves-promoted formal oxidative coupling of aliph. aldehydes with isocyanides)keto amide prepn four component mol sieves catalystSynthesis of alpha -keto amides by a molecular-sieves-promoted formal oxidative coupling of aliphatic aldehydes with isocyanidestext::journal::journal article::research article