Bonne, DamienDekhane, MouloudZhu, Jieping2010-11-252010-11-252010-11-25200510.1021/ja0511220https://infoscience.epfl.ch/handle/20.500.14299/58474One-carbon homologation of aldehyde into amide is realized in one-pot by its reaction with potassium alpha -(p-methoxyphenyl)-alpha -isocyano acetic acid and hydrochloride salt of dimethylamine in toluene at room temp. followed by acidic workup. In this multicomponent reaction, alpha -p-methoxyphenyl-alpha -isocyano acetic acid served as donor of the CONH2 function to aldehyde, while the dimethylamine acted as a shuttle mol. to initiate/terminate the sequence and to mediate the internal redox process of one of the three-component adducts. Ready accessibility, nominal cost of the reagents, and mild conditions are attractive features of the present method. [on SciFinder (R)]Homologation; Oxidation (prepn. of amides via mildoxidative one-carbon homologation using aldehydeamine saltand alpha -isocyano phenylacetate as reactants); Aldehydes Role: RCT (Reactant)RACT (Reactant or reagent) (prepn. of amides via mildoxidative one-carbon homologation using aldehydeamine saltand alpha -isocyano phenylacetate as reactants); Amides Role: SPN (Synthetic preparation)PREP (Preparation) (prepn. of amides via mildoxidative one-carbon homologation using aldehydeamine saltand alpha -isocyano phenylacetate as reactants)mild oxidative one carbon homologation aldehyde amide prepn; aldehyde homologation oxidn amine salt isocyano phenylacetatetext::journal::journal article::research article