Decout, AlexianeAblasser, Andrea2019-06-182019-06-182019-06-182019-05-0610.1016/j.cub.2019.03.031https://infoscience.epfl.ch/handle/20.500.14299/156845WOS:000467138100013The mammalian cyclic dinucleotide 2', 3'-cGAMP is a potent inducer of innate immune responses produced upon detection of cytosolic DNA by cGAS. The mechanisms underlying the control of intracellular cGAMP levels remained unclear. In a new study, Eaglesham et al. identified poxins as 2', 3'-cGAMP-specific nucleases allowing immune evasion by viruses.Biochemistry & Molecular BiologyCell Biologyactivationcgastext::journal::journal article::research article