Stagni, C.Guiducci, C.Benini, L.Ricco, B.Carrara, S.Samori, B.Paulus, C.Schienle, M.Augustyniak, M.Thewes, R.2009-05-122009-05-122009-05-12200610.1109/jssc.2006.884867https://infoscience.epfl.ch/handle/20.500.14299/40056This paper presents a fully electronic label-free DNA chip in 0.5-mu m CMOS technology, with 5-V supply voltage, suitable for low-cost highly integrated applications. The chip features an array of 128 sensor sites with gold electrodes and integrated measurement, conditioning, multiplexing and analog-to-digital conversion circuitry. The circuits measure capacitance variations due to DNA hybridization on the gold electrodes which are bio-modified by covalently attaching probes of known sequence. Specificity, repeatability and parallel detection capability of the fabricated chip are successfully demonstrated.text::journal::journal article::research article