Pelletier, FredericComte, VirginieMassard, AlexandreWenzel, MargotToulot, StephanieRichard, PhilippePicquet, MichelLe Gendre, PierreZava, OlivierEdafe, Fabio2010-12-142010-12-142010-12-14201010.1021/jm1004804https://infoscience.epfl.ch/handle/20.500.14299/62119WOS:000282544800010A series of bimetallic titanium-ruthenium complexes of general formula [(η5-C5H5)(μ-η5:κ1-C5H4(CR12)nPR2R3)TiCl2](η6-p-cymene)RuCl2 (n = 0, 1, 2 or 4; R1 = H or Me; R2 = H, Ph, or Cy; R3 = Ph or Cy) have been synthesized, including two novel compds. as well as two cationic derivs. of formula [(η5-C5H5)(μ-η5:κ1-C5H4(CH2)nPPh2)TiCl2] [(η6-p-cymene)RuCl](BF4) (n = 0 or 2). The solid state structure of two of these compds. was also established by x-ray crystallog. The complexes showed a cytotoxic effect on human ovarian cancer cells and were markedly more active than their Ti or Ru monometallic analogs titanocene dichloride and RAPTA-C, resp. Studies of cathepsin B inhibition, an enzyme involved in cancer progression, showed that enzyme inhibition by the bimetallic complexes is influenced by the length of the alkyl chain in between the metal centers. Complementary ESI-MS studies provided evidence for binding of a Ru(II) fragment to proteins.Estrogen-Receptor ModulatorsIn-VitroAntitumor-ActivitySubstituted TitanocenesBreast-CancerCathepsin-BDichloride DerivativesCytotoxic PropertiesPlatinum CompoundsCrystal-Structuretext::journal::journal article::research article