Buchler, P.Pioletti, Dominique P.Rakotomanana, L. R.2006-07-252006-07-252006-07-25200310.1007/s10237-002-0024-xhttps://infoscience.epfl.ch/handle/20.500.14299/232675A model of tissue differentiation at the bone-implant interface is proposed. The basic hypothesis of the model is that the mechanical environment determines the tissue differentiation. The stimulus chosen is related to the bone-implant micromotions. Equations governing the evolution of the interfacial tissue are proposed and combined with a finite element code to determine the evolution of the fibrous tissue around prostheses. The model is applied to the case of an idealized hip prosthesis.*Bone RemodelingComputer SimulationProsthesis FailureStressMechanicaltext::journal::journal article::research article