Gademann, KarlBethuel, Yann2006-11-222006-11-222006-11-22200410.1021/ol048068xhttps://infoscience.epfl.ch/handle/20.500.14299/235833The first total synthesis of anachelin H is reported. Starting from L-Ser, a stereodivergent synthesis of the polyketide fragment resulting in all possible diastereoisomers is described. The alkaloid peptide fragment is prepared via a tellurium-mediated oxidative aza annulation as the key step. Coupling of the fragments gave synthetic anachelin H, which was found to be identical to a sample of the natural product, thus confirming the configuration by total synthesis.anachelin Htotal synthesisstructure confirmationalkaloidpeptideoxidationaza annulationtext::journal::journal article::research article