Tong, ShuoYang, XuWang, De-XianZhao, LiangZhu, JiepingWang, Mei-Xiang2012-10-012012-10-012012-10-01201210.1016/j.tet.2012.05.108https://infoscience.epfl.ch/handle/20.500.14299/85831WOS:000306267800012The reactivity of stable tertiary enamides in nucleophilic addition reaction with various in-situ generated imines was explored. Under very mild conditions, formyl-bearing tertiary enamides reacted with both aromatic and aliphatic amines to form imine intermediates. In the absence or presence of p-toluenesulfonic acid as a catalyst, intramolecular nucleophilic addition of enamide to imine functionality proceeded effectively to produce diverse 4-amino-1,2,3,4-tetrahydropyridine derivatives in good to excellent yields.Chiral Bronsted Acid3-Component Povarov ReactionClausena-AlkaloidsHighly EfficientEnantioselective SynthesisCgp 498234-AminopiperidinesPiperidinesCyclizationAntagonistsSynthesis of 4-amino-1,2,3,4-tetrahydropyridine derivatives by intramolecular nucleophilic addition of tertiary enamides to in-situ generated iminestext::journal::journal article::research article