Laib, TaouesChastanet, JacquelineZhu, Jieping2010-11-252010-11-252010-11-25199710.1016/S0040-4039(97)00207-4https://infoscience.epfl.ch/handle/20.500.14299/58547An efficient asym. synthesis of (2S,3S)-beta -hydroxyleucine is described. The key step in the synthesis was a highly diastereoselective nucleophilic addn. of Grignard reagent to N,N-dibenzyl-O-TBS-serinal (TBS = SiMe2CMe3). This strategy should be applicable to the synthesis of other related beta -hydroxy amino acids. [on SciFinder (R)]Amino acids Role: SPN (Synthetic preparation)PREP (Preparation) (hydroxy; asym. synthesis of hydroxyleucine via stereoselective Grignard addn.); Asymmetric synthesis and induction (of hydroxyleucine via stereoselective Grignard addn.); Grignard reaction (stereoselective; asym. synthesis of hydroxyleucine via stereoselective Grignard addn.)asym synthesis hydroxyleucine; leucine hydroxy asym synthesis; hydroxy amino acid asym synthesis; stereoselective Grignard amino aldehydetext::journal::journal article::research article