Aztekin, Can2021-08-142021-08-142021-08-142021-07-2810.1098/rsob.210126https://infoscience.epfl.ch/handle/20.500.14299/180565WOS:000679965000001Species that can regrow their lost appendages have been studied with the ultimate aim of developing methods to enable human limb regeneration. These examinations highlight that appendage regeneration progresses through shared tissue stages and gene activities, leading to the assumption that appendage regeneration paradigms (e.g. tails and limbs) are the same or similar. However, recent research suggests these paradigms operate differently at the cellular level, despite sharing tissue descriptions and gene expressions. Here, collecting the findings from disparate studies, I argue appendage regeneration is context dependent at the cellular level; nonetheless, it requires (i) signalling centres, (ii) stem/progenitor cell types and (iii) a regeneration-permissive environment, and these three common cellular principles could be more suitable for cross-species/paradigm/age comparisons.Biochemistry & Molecular Biologyappendage regenerationcross-speciesregenerationsingle-cell-omicscellular levelxenopus tadpole tailapical ectodermal ridgedigit tip regenerationlimb regenerationspinal-cordblastema formationepidermal capzebrafish finmuscle regenerationclonal analysistext::journal::journal article::review article