Willot, MatthieuChen, Jin ChunZhu, Jieping2010-11-252010-11-252010-11-25200910.1055/s-0028-1087566https://infoscience.epfl.ch/handle/20.500.14299/58391A combination of weak Lewis acid (LiCl) and weak Bronsted acid (hexafluoroisopropanol, HFIP) promotes efficiently the Friedel-Crafts reaction of electron-rich arom. compds. with Et glyoxylate. [on SciFinder (R)]Friedel-Crafts reaction; Friedel-Crafts reaction catalysts (Friedel-Crafts hydroxyalkylation of electron-rich arenes with glyoxylate using lithium chloride and fluoroisopropanol as catalyst); Lewis acids Role: CAT (Catalyst use)USES (Uses) (Friedel-Crafts hydroxyalkylation of electron-rich arenes with glyoxylate using lithium chloride and fluoroisopropanol as catalyst); Alcohols Role: SPN (Synthetic preparation)PREP (Preparation) (aralkyl; Friedel-Crafts hydroxyalkylation of electron-rich arenes with glyoxylate using lithium chloride and fluoroisopropanol as catalyst); Aromatic hydrocarbons Role: RCT (Reactant)SPN (Synthetic preparation)PREP (Preparation)RACT (Reactant or reagent) (electron-rich; Friedel-Crafts hydroxyalkylation of electron-rich arenes with glyoxylate using lithium chloride and fluoroisopropanol as catalyst); Carboxylic acids Role: SPN (Synthetic preparation)PREP (Preparation) (hydroxyesters; Friedel-Crafts hydroxyalkylation of electron-rich arenes with glyoxylate using lithium chloride and fluoroisopropanol as catalyst)arene glyoxylate Friedel Crafts hydroxyalkylation lithium chloride fluoroisopropanol catalyst; arylglycolate prepn; mandelate prepntext::journal::journal article::research article