Racine, EmilieBello, ClaudiaGerber-Lemaire, SandrineVogel, PierrePy, Sandrine2009-01-162009-01-162009-01-16200910.1021/jo802255thttps://infoscience.epfl.ch/handle/20.500.14299/33808WOS:000263316600049The ketonitrone 8 was prepared from D-fructose as an inexpensive starting material, and was used in a stereoselective synthesis of 1-deoxymannojirimycin (4), its previously unknown N-hydroxy analogue 15, as well as the polyhydroxylated ketonitrone 14. The latter were assayed as potential glycosidase inhibitors on a panel of 13 selected purified enzymes. N-Hydroxy DMJ (15) exhibited a moderate and non selective activity towards the snail - mannosidase EC 3.2.1.25.1,3-Dipolar Cycloaddition ReactionsLysosomal Storage DisordersNatural-Product Sb-219383Transfer-Rna SynthetaseCyclic NitronesGlycosidase InhibitorsDiastereoselective SynthesisAbsolute-ConfigurationMannosidase InhibitorAsymmetric-Synthesistext::journal::journal article::research article