Barde, IsabelleLaurenti, ElisaVerp, SoniaGroner, Anna ClaireTowne, ChristopherPadrun, VivianeAebischer, PatrickTrumpp, AndreasTrono, Didier2009-05-252009-05-252009-05-25200910.1128/JVI.00001-09https://infoscience.epfl.ch/handle/20.500.14299/40230WOS:000266034100027KAP1 is an essential cofactor of KRAB zinc finger proteins, a family of vertebrate-specific epigenetic repressors of largely unknown functions encoded in the hundreds by the mouse and human genomes. So far, KRAB/KAP1-mediated gene regulation has been studied within the environment of chromosomal DNA. Here we demonstrate that KRAB/KAP1 regulation is fully functional within the context of episomal DNA, such as adeno-associated viral and nonintegrated lentiviral vectors, and is correlated with histone modifications typically associated with this epigenetic regulator.KAP1KRABAAVtext::journal::journal article::research article