Yao, BoWang, QianZhu, Jieping2015-05-052015-05-052015-05-05201510.1002/chem.201501020https://infoscience.epfl.ch/handle/20.500.14299/113698WOS:000354027300019A palladium-catalyzed cyclizative cross-coupling of two o-alkynylanilines to 2,3’-bisindoles under aerobic oxidative conditions was developed. Mechanistic studies suggested that the two catalytic cycles, namely the formation of 3-alkynylindoles 8 and their subsequent cyclization to bisindoles 5, are temporally separated. The aminopalladation of 3-alkynylindoles 8 occurred only after all the N,N-dialkyl-o-alkynylanilines were consumed. The solid support (activated charcoal) played a crucial role in the second intramolecular aminopalladation process.aerobic oxidative conditionsbisindolescyclizative cross-couplingo-alkynylanilinepalladiumtext::journal::journal article::research article