Marziali, G.Perrotti, E.Ilari, R.Lulli, V.Coccia, E. M.Mazzeo, S.Kühn, L. C.Testa, U.Battistini, A.2008-02-252008-02-252008-02-25200210.1006/bcmd.2002.0595https://infoscience.epfl.ch/handle/20.500.14299/19090Members of the Ets gene family are known to be expressed in the hematopoietic tissue and some of them play a pivotal role in normal hematopoietic cell development. Ets-1 gene expression was analyzed in Friend Leukemia Cells (FLC) induced to erythroid differentiation by DMSO. We show that the level of Ets-1 protein and its binding activity decreases in FLC along erythroid differentiation of primary human progenitors. The same behavior was observed during normal erythroid differentiation. Moreover, FLC constitutively expressing Ets-1 show a decrease in TfR gene expression, globin mRNA and hemoglobin synthesis. These data indicate that a decrease in Ets-1 binding activity is required for a normal erythroid maturation and that a deregulated expression of this transcription factor may interfere with terminal erythroid differentiation.text::journal::journal article::research article