Ondi, LeventeVolle, Jean-NoelSchlosser, Manfred2006-03-032006-03-032006-03-03200510.1016/j.tet.2004.10.053https://infoscience.epfl.ch/handle/20.500.14299/227047WOS:000226484200024Mono- and disubstituted 2-bromo-3-fluoroquinolines are readily accessible. They can be converted into the 3-fluoroquinoline-2-carboxylic acids by consecutive halogen/metal permutation and into the 2-bromo-3-fluoroquinoline-4-carboxylic acids by consecutive deprotonation and carboxylation. The latter compds. can be reduced to afford the 3-fluoroquinoline-4-carboxylic acids. The yields are excellent throughout. Rather than introduction of one functional group alternatively at the 2- or 4-position, one may also attach two different functional groups sequentially to both sites. [on SciFinder (R)]Carboxylation (metalation/functionalization sequences applied to 2-bromo-3-fluoroquinolines)metalation functionalization bromofluoroquinoline; quinoline bromofluoro metalation functionalization; quinolinecarboxylic acid prepntext::journal::journal article::research article