A Novel Multicomponent Synthesis of Polysubstituted 5-Aminooxazole and Its New Scaffold-Generating Reaction to Pyrrolo[3,4-b]pyridine

Sun, XiaowenJanvier, PierreZhao, GangBienayme, HuguesZhu, Jieping2010-11-252010-11-252010-11-25200110.1021/ol007055qhttps://infoscience.epfl.ch/handle/20.500.14299/58510A novel three-component synthesis of 5-aminooxazoles is reported. Its subsequent reaction with alpha ,beta -unsatd. acyl chloride leads to polysubstituted pyrrolopyridines. A triple domino process, acylation/IMDA/retro-Michael cycloreversion, was involved in the latter process. The methodol. allows the quick prepn., from simple and readily available inputs, of highly functionalized title compds. not easily accessed by other methods. [on SciFinder (R)]aminooxazole prepn reaction acyl chloride; pyrrolopyridine prepnA Novel Multicomponent Synthesis of Polysubstituted 5-Aminooxazole and Its New Scaffold-Generating Reaction to Pyrrolo[3,4-b]pyridinetext::journal::journal article::research article