Synthesis of Functionalized Spiroindolines via Palladium-Catalyzed Methine C-H Arylation

Saget, TanguyPerez, DavidCramer, Nicolai2013-05-132013-05-132013-05-13201310.1021/ol400380yhttps://infoscience.epfl.ch/handle/20.500.14299/92177WOS:000316520300051The synthesis of cyclopropyl spiroindolines is described using an intramolecular palladium(0)-catalyzed C-H functionalization of a methine C(sp(3))-H bond. This transformation can be coupled with intermolecular Suzuki couplings or direct arylations of heteroaromatics to access functionalized indoline scaffolds in a single step.Synthesis of Functionalized Spiroindolines via Palladium-Catalyzed Methine C-H Arylationtext::journal::journal article::research article