Vechorkin, OlegBarmaz, DelphineProust, ValérieHu, Xile2009-08-062009-08-062009-08-06200910.1021/ja906040thttps://infoscience.epfl.ch/handle/20.500.14299/41986WOS:000269379600029Ni-catalyzed Sonogashira coupling of nonactivated, β-H- containing alkyl halides, including chlorides, is reported. The coupling is tolerant to a wide range of functional groups, including ether, ester, amide, nitrile, keto, heterocycle, acetal, and aryl halide, in both coupling partners. The coupling can be selective for a specific C−X bond (X = I, Br, Cl) and allows for orthogonal functionalization of alkyl halides with multiple reactive sites.Grignard-ReagentsNickel-ComplexesCross-CouplingsAcetylidesLigandNi-Catalyzed Sonogashira Coupling of Non-activated Alkyl Halides: Orthogonal Functionalization of Alkyl Iodides, Bromides, and Chloridestext::journal::journal article::research article