Yue, TaoWang, Mei-XiangWang, De-XianMasson, GeraldineZhu, Jieping2010-11-252010-11-252010-11-25200910.1021/jo9017765https://infoscience.epfl.ch/handle/20.500.14299/58388A chiral Lewis acid catalyst was prepd. by mixing 2 equiv of chiral binol-derived organophosphoric acid and 1 equiv of Et2AlCl. In the presence of a catalytic amt. of [I]2Al(III)Cl complex (0.05 equiv), reaction between alpha -isocyanoacetamides and aldehydes afforded the corresponding 5-aminooxazoles, e.g. II, in good yields and enantioselectivities. Complex [I]2Al(III)Cl isolated as a white solid displayed similar reactivity as that prepd. in situ. [on SciFinder (R)]Aldehydes; Isocyanides Role: RCT (Reactant)RACT (Reactant or reagent) (stereoselective prepn. of aminooxazoles via Al-organophosphate-catalyzed asym. Passerini-type reaction of alpha -isocyanatoacetamides and aldehydes); Passerini reaction; Passerini reaction catalysts (stereoselective; stereoselective prepn. of aminooxazoles via Al-organophosphate-catalyzed asym. Passerini-type reaction of alpha -isocyanatoacetamides and aldehydes)organophosphate aluminum catalyst isocyanoacetamide aldehyde asym Passerini type reaction; aminooxazole stereoselective prepntext::journal::journal article::research article