Gay, S.Martoccia, C.Zellweger, MatthieuWang, Q.Wagnières, Georges2014-01-272014-01-272014-01-27201410.3998/ark.5550190.p008.469https://infoscience.epfl.ch/handle/20.500.14299/100179WOS:000343046700016Photodynamic therapy based on photoactivable porphyrins (PAPs) can treat various dermatological conditions. The side-effects as well as the non-selective or insufficient accumulation of PAPs in the targeted tissues limit performances. We studied the stability in solution at different temperatures (21 degrees C; 4 degrees C), different pH values (7.5; 2.0), and as a function of time of 5-aminolevulinic acid's Tyrosine-ester, a molecule presenting interesting properties to selectively produce PAPs in blood vessels after topical application. Solutions of this precursor can be kept up to 24 h at refrigerated temperatures and under acidic pH. At room temperature or physiological pH, they must be prepared minutes before their use.5-Aminolevulinic acidstability5-aminolevulinic acid derivativesphotodynamic therapytyrosine estertext::journal::journal article::research article