Yoshihara, Hikari A. I.Can, EmineKarlsson, MagnusLerche, Mathilde H.Schwitter, JuergComment, Arnaud2016-07-192016-07-192016-07-19201610.1039/c6cp00589fhttps://infoscience.epfl.ch/handle/20.500.14299/127708WOS:000375689200002[1-C-13]pyruvate is the most widely used hyperpolarized metabolic magnetic resonance imaging agent. Using a custom-built 7.0 T polarizer operating at 1.0 K and trityl radical-doped [1-C-13] pyruvic acid, unextrapolated solution-state C-13 polarization greater than 60% was measured after dissolution and rapid transfer to a spectrometer magnet, demonstrating the signal enhancement attainable using optimized hardware. Slower rates of polarization under these conditions can be largely overcome with higher radical concentrations.text::journal::journal article::research article