Houten, Sander MAuwerx, Johan2009-04-022009-04-022009-04-02200410.1016/j.cell.2004.09.016https://infoscience.epfl.ch/handle/20.500.14299/3683215454076PGC-1alpha plays essential and diverse functions in the control of metabolism ranging from mitochondrial biogenesis and respiration to hepatic gluconeogenesis and muscle fiber-type switching. In a paper in this issue of Cell, the characterization of PGC-1alpha(-/-) mice illustrates these pleiotropic functions and reveals an unexpected role for PGC-1alpha in the brain.text::journal::journal article::review article