Tran, Duc N.Cramer, Nicolai2011-08-172011-08-172011-08-17201110.2533/chimia.2011.271https://infoscience.epfl.ch/handle/20.500.14299/70131WOS:000290699400018The direct functionalization of carbon-hydrogen bonds is an emerging tool to establish more sustainable and efficient synthetic methods. We present its implementation in a cascade reaction that provides a rapid assembly of functionalized indanylamines from simple and readily available starting materials. Careful choice of the ancillary ligand - an electron-rich bidentate phosphine ligand - enables highly diastereoselective rhodium(I)-catalyzed intramol. allylations of unsubstituted ketimines induced by a directed C-H bond activation and allene carbo-metalation sequence.AlleneAllylationC-H ActivationCatalysisRhodiumQuaternary Stereogenic CentersBond FormationEnantioselective SynthesisReverse PrenylationActivationCleavageFunctionalizationArylationConstructionDerivativestext::journal::journal article::research article