Byrn, R. A.Mordenti, J.Lucas, C.Smith, D.Marsters, S. A.Johnson, J. S.Cossum, P.Chamow, S. M.Wurm, F. M.Gregory, T.2007-06-052007-06-052007-06-05199010.1038/344667a0https://infoscience.epfl.ch/handle/20.500.14299/76221970124Molecular fusions of CD4, the receptor for human immunodeficiency virus (HIV), with immunoglobulin (termed CD4 immunoadhesins) possess both the gp120-binding and HIV-blocking properties of recombinant soluble CD4, and certain properties of IgG, notably long plasma half-life and Fc receptor binding. Here we show that a CD4 immunoadhesin can mediate antibody-dependent cell-mediated cytotoxicity (ADCC) towards HIV-infected cells, although, unlike natural anti-gp120 antibodies, it does not allow ADCC towards uninfected CD4-expressing cells that have bound soluble gp120 to the CD4 on their surface. In addition, CD4 immunoadhesin, like natural IgG molecules, is efficiently transferred across the placenta of a primate. These observations have implications for the therapeutic application of CD4 immunoadhesins, particularly in the area of perinatal transmission of HIV infection.Acquired Immunodeficiency Syndrome/congenital/immunologyAnimalsAntibodiesAnti-Idiotypic/*immunologyAntibody-Dependent Cell Cytotoxicity/immunologyAntigensCD/*immunologyCD4 ImmunoadhesinsCD4-Positive T-Lymphocytes/immunology/microbiologyFemaleHIV/*immunologyHIV Envelope Protein gp120/immunologyHumansImmunityMaternally-AcquiredImmunoglobulin G/*immunologyMacaca mulattaPregnancyRecombinant Proteinstext::journal::journal article::research article