Goemans, Camille2025-10-032025-10-032025-10-022025-07-1810.1016/j.tibs.2025.07.003https://infoscience.epfl.ch/handle/20.500.14299/254645The gut microbiota harbors a vast array of enzymes, many with unknown functions. In a recent study, Probst et al. mined this ecosystem to identify potential defluorinating enzymes. Combining molecular dynamics, alanine scanning, and machine learning, they uncovered molecular features critical for defluorination enzymatic activity in human gut microbes.entext::journal::journal article::research article