Jongen, NathalieLemaitre, JacquesBowen, PaulDonnet, MarcelSchiewe, JoergZierenberg, BerndSoare, Lucica2015-09-222015-09-222015-09-222004https://infoscience.epfl.ch/handle/20.500.14299/118393The invention relates to an improved process for the production of powders of an inhalable medicament by crystallization from a supersaturated fluid containing said medicament, the method comprising passing along a tubular reactor(a) a segmented flow of that fluid comprised of discrete volumes or(b) a fluid mixture being separated by discrete volumes of a separating fluid which is substantially immiscible with said fluid,characterized in that the crystallization is initiated by application of ultrasound.patentUS8496944CA2502502JP5172075AT551993EP1585585US2009068275JP2006504746EP1585585US2004197275WO2004034943AU2003267433AU2003267433CA2502502WO20040349433310176132103884