Boisnard, SabineCarbonnelle, Anny-ClaudeZhu, Jieping2010-11-252010-11-252010-11-25200110.1021/ol016021vhttps://infoscience.epfl.ch/handle/20.500.14299/58514Palladium-catalyzed Suzuki cross-coupling, Corey's enantioselective alkylation of glycine template, and macrolactamization are key steps in an efficient synthesis of the 15-membered macrocycle I, the A-B biaryl macrocyclic component of RP-66453 (II). Unfortunately, the cyclization of I by various methods (varying the base, the solvent and the temp.) did not provide the desired macrocycle II. [on SciFinder (R)]Macrocyclic compounds Role: SPN (Synthetic preparation)PREP (Preparation) (biaryl; total synthesis of the fully functionalized biarylmacrocyclic component of RP-66453); Cyclization (lactamization; total synthesis of the fully functionalized biarylmacrocyclic component of RP-66453); Alkylation (stereoselectiveCorey; total synthesis of the fully functionalized biarylmacrocyclic component of RP-66453); Suzuki coupling reaction (total synthesis of the fully functionalized biarylmacrocyclic component of RP-66453)RP66453 biaryl macrocycle component total synthesistext::journal::journal article::research article