Renteria-Gomez, AngelTorres-Ochoa, Ruben O.Gamez-Montano, RocioWang, QianZhu, Jieping2020-10-012020-10-012020-10-012020-09-0410.1021/acs.orglett.0c02578https://infoscience.epfl.ch/handle/20.500.14299/172050WOS:000569377600065In the presence of a catalytic amount of Pd(OAc)(2) and XantPhos, the three-component reaction of ynones, imines, and aryl iodides affords fully substituted alkylidene-furan-3(2H)-ones via a sequence of the Mannich reaction followed by chemo- and regioselective oxypalladation and reductive elimination. One carbon-oxygen and two carbon-carbon bonds are generated to afford the heterocycle in good to excellent yield.Chemistry, OrganicChemistrydomino reaction3(2h)-furanonescyclizationderivativesnitrilesannulationalkenesynonesacidsheteroannulationtext::journal::journal article::research article