Palladium-Catalyzed Through-Space C(sp3)-H and C(sp2)-H Bond Activation by 1,4-Palladium Migration: Efficient Synthesis of [3,4]- Fused Oxindoles

Piou, TiffanyBunescu, AlaWang, QianNeuville, LucZhu, Jieping2013-11-132013-11-132013-11-13201310.1002/anie.201306532https://infoscience.epfl.ch/handle/20.500.14299/96993WOS:000326807900037Palladium two step: Linear anilides were converted into the title compounds in good to excellent yields through a palladium-catalyzed domino carbopalladation/1,4-palladium shift sequence. The C(sp3)-H activation involves a seven-membered palladacycle, and is chemoselective in the presence of competitive C(sp2)H bonds. DMA=N,N-dimethylacetamide, OPiv=pivalate.C-H activationheterocyclespalladiumchemoselectivityPalladium-Catalyzed Through-Space C(sp3)-H and C(sp2)-H Bond Activation by 1,4-Palladium Migration: Efficient Synthesis of [3,4]- Fused Oxindolestext::journal::journal article::research article