A Factor Two Improvement in High-Field Dynamic Nuclear Polarization from Gd(III) Complexes by Design

Stevanato, GabrieleKubicki, Dominik JozefMenzildjian, GeorgesChauvin, Anne-SophieKeller, KatharinaYulikov, MaximJeschke, GunnarMazzanti, MarinellaEmsley, Lyndon2019-06-242019-06-242019-06-242019-06-0510.1021/jacs.9b03723https://infoscience.epfl.ch/handle/20.500.14299/158437WOS:000470939200018Gadolinium(III) complexes have recently been demonstrated to have potential as polarizing agents for high-field dynamic nuclear polarization (DNP) NMR spectroscopy. By tailoring the ligand design to reduce the zero-field splitting (ZFS), we demonstrate a quadratic improvement in DNP through the investigation of a stable, water-soluble, narrow-line Gd(III) complex, [Gd-(tpatcn)], doubling the magic-angle-spinning DNP enhancement of the previous state-of-the-art [Gd(dota)-(H2O)](-) at 9.4 T and 100 K.Chemistry, MultidisciplinaryChemistrymri contrast agentspolarizing agentssolid-statenmr-spectroscopyefficienteprtemperaturesrelaxationA Factor Two Improvement in High-Field Dynamic Nuclear Polarization from Gd(III) Complexes by Designtext::journal::journal article::research article