Wang, YangWang, QianZhu, Jieping2016-06-092016-06-092016-06-09201610.1002/chem.201601548https://infoscience.epfl.ch/handle/20.500.14299/126567WOS:000380269400013The first catalytic asymmetric inverse electron demand 1,3-dipolar cycloaddition of azomethine imines with enecarbamates has been developed. Isoquinolinefused pyrazolidines containing two or three contiguous stereogenic centers were obtained in high yields with excellent regio-, diastereo-, and enantioselectivities. The pyrazolidine ring can be opened to install an aminal, a amino nitrile, or homoallylamine function with an excellent control of the newly generated stereogenic center. Access to aminobenzo[a]quinolizidine is also documented.azomethinescarbamatescycloadditionorganocatalysistetrahydroisoquinolinesChiral Phosphoric Acid-Catalyzed Enantioselective Formal [3+2] Cycloaddition of Azomethine Imines with Enecarbamatestext::journal::journal article::research article