Perez, Caleb R.De Palma, Michele2020-01-022020-01-022020-01-022019-11-2710.1038/s41467-019-13368-yhttps://infoscience.epfl.ch/handle/20.500.14299/164282WOS:000503185700001At the interface between the innate and adaptive immune system, dendritic cells (DCs) play key roles in tumour immunity and hold a hitherto unrealized potential for cancer immunotherapy. Here we review the role of distinct DC subsets in the tumour microenvironment, with special emphasis on conventional type 1 DCs. Integrating new knowledge of DC biology and advancements in cell engineering, we provide a blueprint for the rational design of optimized DC vaccines for personalized cancer medicine.Multidisciplinary SciencesScience & Technology - Other Topicskinase 3 ligandcross-presentationlymph-nodesin-vitroantigen-presentationmelanoma patientshuman bloodifn-gammacd8(+)responsestext::journal::journal article::research article