Iron-Catalyzed Mizoroki–Heck Cross-Coupling Reaction with Styrenes

Loska, RafalVolla, Chandra M RaoVogel, Pierre2008-12-192008-12-19200810.1002/adsc.200800662https://infoscience.epfl.ch/handle/20.500.14299/32868WOS:000262320900004In the presence of iron(II) chloride (FeCl2 ; 20 mol%) and potassium tert-butoxide (t- BuOK; 4 equiv.) in dimethyl sulfoxide (DMSO), aryl and heteroaryl iodides undergo stereoselective Mizoroki–Heck C—C cross-coupling reactions with styrenes at 60 8C giving the corresponding (E)-alkenes. The best yields are obtained upon adding a ligand (80 mol%) such as proline or picolinic acid. Aryl bromides and pyridinyl bromides are also coupled with styrenes but in lower yields.alkenesC-C cross-couplinggreen chemistryiron catalysisMizoroki–Heck reactionpicolinic acidIron-Catalyzed Mizoroki–Heck Cross-Coupling Reaction with Styrenestext::journal::journal article::research article