Zheng, Sheng-CaiWang, QianZhu, Jieping2019-01-302019-01-302019-01-30201910.1002/anie.201812654https://infoscience.epfl.ch/handle/20.500.14299/154178We report herein the first examples of catalytic enantioselective synthesis of axially chiral 3-arylpyrroles. Reaction of a-isocyanoacetates with b-aryl-a,b-alkynic ketones in the presence of silver oxide and a phosphine ligand derived from Cinchona alkaloid occurred chemoselectively to afford enantioenriched 3-arylpyrroles in high yields with excellent enantiomeric excesses. The pyrrole ring was constructed de novo in this process.arylpyrrole · asymmetric synthesis · axial chirality ·homogeneous catalysis · isocyanideCatalytic Atropenantioselective Heteroannulation between Isocyanoacetates and Alkynyl Ketones: Synthesis of Enantioenriched Axially Chiral 3-Arylpyrrolestext::journal::journal article::research article