Zambron, Bartosz K.Dubbaka, Srinivas R.Markovic, DeanMoreno-Clavijo, ElenaVogel, Pierre2013-10-012013-10-012013-10-01201310.1021/ol401053yhttps://infoscience.epfl.ch/handle/20.500.14299/95355WOS:000319720900057An efficient method has been developed for the preparation of yet unknown acyclic mixed anhydrides of carboxylic and sulfinic acids. Sterically hindered 2-methylbut-3-ene-2-sulfinyl carboxylates add primary and secondary amines preferentially onto the carbonyl moieties realizing a new method for the one-pot preparation of carboxamides. It uses 1:1 mixtures of carboxylic acids and amines without a base, requires no excess of reagents, and liberates only volatile coproducts. Protected di- and tripeptides have been prepared in solution without epimerization by application of this method.text::journal::journal article::research article