Mapping of positive selection sites in the HIV-1 genome in the context of RNA and protein structural constraints

Snoeck, JokeFellay, JacquesBartha, IstvanDouek, Daniel C.Telenti, Amalio2012-06-122012-06-122012-06-12201110.1186/1742-4690-8-87https://infoscience.epfl.ch/handle/20.500.14299/81566WOS:000297754800001Background: The HIV-1 genome is subject to pressures that target the virus resulting in escape and adaptation. On the other hand, there is a requirement for sequence conservation because of functional and structural constraints. Mapping the sites of selective pressure and conservation on the viral genome generates a reference for understanding the limits to viral escape, and can serve as a template for the discovery of sites of genetic conflict with known or unknown host proteins.Hivevolutionpositive selectionRNA structureOverlapping GenesEvolutionInfectionTransmissionAdaptationMutationMapping of positive selection sites in the HIV-1 genome in the context of RNA and protein structural constraintstext::journal::journal article::research article