Li, Sheng YuYuan, ShanshanZhao, Xiao MingWang, QunlongZhu, JiepingZheng, Sheng Cai2025-03-202025-03-202025-03-19202510.1016/j.checat.2024.1012622-s2.0-86000361623https://infoscience.epfl.ch/handle/20.500.14299/248078Extensive research has been conducted on chiral porphyrin-metal complex (M = Co, Rh, Ru, Fe)-catalyzed asymmetric cyclopropanation of alkenes. However, the corresponding iridium complex has scarcely been exploited for this purpose. We report herein that the reaction of 2,2,2-trichloroethyl (TCE) α-aryldiazoacetates 1 with alkenes 2 in the presence of a catalytic amount of [Ir(Por∗)(CO)Cl] (1.0 mol %) yields a single diastereomer of 1,1,2-trisubstituted cyclopropanes in high yields with excellent enantioselectivities. A β-axially chiral porphyrin, developed recently in our laboratory, serves as an efficient supporting ligand.falseaxial chiralitychiral porphyrincyclopropanationiridium porphyrin complexSDG9: Industry, innovation, and infrastructureα-aryldiazoacetateHighly diastereoselective and enantioselective cyclopropanation of alkenes catalyzed by a chiral iridium(III) porphyrin complextext::journal::journal article::research article