Human chromosome 21 is necessary and sufficient to confer human IFN gamma responsiveness to somatic cell hybrids expressing the cloned human IFN gamma receptor gene

Fischer, T.Rehm, A.Aguet, M.Pfizenmaier, K.2007-12-122007-12-122007-12-12199010.1016/1043-4666(90)90010-Qhttps://infoscience.epfl.ch/handle/20.500.14299/15416The human interferon (IFN) gamma receptor cDNA has been stably expressed in human/mouse somatic cell hybrids, which differ in their content of human chromosome 21. Despite high affinity IFN gamma binding-capacity of all receptor transfectants, biological responsiveness to IFN gamma, as determined by enhancement of mouse-MHC class I gene expression, required the presence of chromosome 21. These data suggest complementation of at least two functionally distinct components in order to create a biologically active IFN gamma receptor.Human chromosome 21 is necessary and sufficient to confer human IFN gamma responsiveness to somatic cell hybrids expressing the cloned human IFN gamma receptor genetext::journal::journal article::research article