Stumpf, Bernd HenningAmbriovic-Ristov, AndrejaRadenovic, AleksandraSmith, Ana-Suncana2020-12-312020-12-312020-12-312020-12-0410.3389/fphys.2020.574371https://infoscience.epfl.ch/handle/20.500.14299/174386WOS:000599620900001Nascent adhesions are submicron transient structures promoting the early adhesion of cells to the extracellular matrix. Nascent adhesions typically consist of several tens of integrins, and serve as platforms for the recruitment and activation of proteins to build mature focal adhesions. They are also associated with early stage signaling and the mechanoresponse. Despite their crucial role in sampling the local extracellular matrix, very little is known about the mechanism of their formation. Consequently, there is a strong scientific activity focused on elucidating the physical and biochemical foundation of their development and function. Precisely the results of this effort will be summarized in this article.PhysiologyPhysiologynascent adhesionsfocal adhesionsintegrin activationintegrin clusteringsuperresolution microscopymodelingplacebo-controlled trialtalin head domainintegrin activationtransmembrane domainsignal-transductionstructural basisfocal adhesionscell-adhesiondynamicsfaktext::journal::journal article::review article