Gilbert, B.Perfetti, L.Hansen, R.Mercanti, D.Ciotti, M. T.Casalbore, P.Andres, R.Perfetti, P.Margaritondo, G.De Stasio, G.2006-10-032006-10-032006-10-03200010.2741/A488https://infoscience.epfl.ch/handle/20.500.14299/234839WOS:0000896630000012771UV/ozone ashing of thin tissue sections and cell cultures is a simple technique to enhance relative elemental concentrations, while maintaining their spatial location at the sub-micron level. This approach may enhance the capability of spatially resolved analysis techniques to detect the distribution of trace elements in biological matrices. We present results from light microscopy and x-ray spectromicroscopy studies of tissues and cells demonstrating that the micro-structure is very well conserved. We show the signal enhancement resulting from the removal of carbon, which allows otherwise undetectable gadolinium to be mapped in cancer tissue for a novel neutron capture therapy.ashingmicrochemical analysistrace element detectionspectromicroscopySPECTROMICROSCOPYMEPHISTOCULTURESSPECTROMICROSCOPYtext::journal::journal article::research article